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KMID : 0604219990060010009
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Korean Journal Investigative Dermatology
1999 Volume.6 No. 1 p.9 ~ p.16
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Transcriptional Regulation of Type I Collagen Genes: Role of Transforming Growth Factor-β and Tumor Necrosis Factor-α
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Chung KY
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Abstract
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In mammals, collagen accounts for about 30% of animal proteins and thus is the
single most abundant protein. In human dermis, the proportion is even higher,
constituting about 70% of the dry weight and it functions as the main structural
element. The fluctuation and the resultant balance between production and degradation
of collagen plays an essential role in maintaining the homeostasis of every tissue. For
example, overproduction of type I collagen results in scleroderma or pulmonary fibrosis,
and defect in its structure is manifested by osteogenesis imperfecta. Therefore, clarifying
the mechanisms of how production and degradation of type I collagen is regulated is the
basis for understanding and overcoming these disease processes which are still puzzling
to mankind.
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KEYWORD
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